INNOVANCE PFA-200 System*

The INNOVANCE PFA-200 System’s unique technology simulates in vitro hemodynamic conditions of platelet adhesion and aggregation in a vascular lesion, providing rapid detection of acquired, inherited, or drug-induced platelet dysfunction in multiple clinical settings. Combining the INNOVANCE PFA^® P2Y test*, the Dade^® PFA Collagen/EPI Test Cartridge, and the Dade PFA Collagen/ADP Test Cartridge provides a comprehensive, cost-effective preoperative bleeding risk solution.

• Simple 3-step process requires minimal pipetting and hands-on time
• Results from one 800 μL sample of blood
• One cut-off for P2Y samples in 3.2 and 3.8% buffered sodium
• Preoperative screening results in 5-8 minutes

In combination with traditional coagulation screening tests such as prothrombin time and activated partial thromboplastin time, the INNOVANCE PFA-200 System provides excellent sensitivity to functional defects of hemostasis.

• Accurate detection of acquired, inherited, or drug-induced platelet dysfunction under high-shear stress
• Sensitive to quantitative and qualitative abnormalities of VWD in both plasma and platelets
• Simple, rapid, semi-quantitative, and precise assessment of platelet function
• Software supports closure curve¹ illustrations for use in scientific studies

The INNOVANCE PFA-200 System assesses whether doses are sufficient to induce platelet dysfunction. While other analyzers only detect the inhibition of platelet aggregation, the INNOVANCE PFA-200 System accurately measures the ability of aspirin to prevent platelet plug formation.

Several “screening tests” fail to detect a number of mild bleeding disorders that could cause substantial bleeding. The INNOVANCE PFA-200 System, however, can reliably identify patients with a bleeding risk due to platelet function deficiency. With the INNOVANCE PFA-200 System, most patients with prolonged Col/ADP Closure Times manifest abnormalities in primary hemostasis that could place them at risk during surgery.

• The Dade PFA Collagen/EPI Test Cartridge provides effective assessment of pre-surgical therapy with desmopressin (DDAVP)
• Several clinical studies suggest that the PFA closure time (CT) with both the Dade PFA Collagen/EPI and Dade PFA Collagen/ADP Test Cartridges becomes measurably shorter following infusion of DDAVP
• Shorter closure times indicate improved platelet function and may indicate improvement in bleeding symptoms and transfusion needs

• No special sample collection requirements–only a small volume of citrated whole blood is needed (800 μL)
• All PFA tests can be run from one patient sample tube
• All biological material remains in the test cartridge. This feature minimizes operator/blood contact for improved safety and consistency, avoiding instrument contamination and facilitating safe biohazard disposal
• Blood samples are stable for up to 4 hours after collection
• Built-in quality control program reduces risk of reporting false results
• Password/access levels protect sensitive patient data and provide enhanced traceability records